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Amine compounds containing a catechol ring catecholamines (dihydroxy benzene) are. These include dopamine, norepinephrine and epinephrine, and their respective metabolites. In the bio-synthesis of the enzyme tyrosine hydroxylase catecholamines first amino acid tyrosine to LDopa by turns. Tyrosine hydroxylase tissue source of catecholamines, which is mainly related to dopaminergic les oscars neurons and Nvradrnvzhyk greatly les oscars limited the central les oscars nervous system and the sympathetic system and the adrenaline medullary tissue environment.
LDopa by enzymes, amino acids and carboxylase les oscars is converted to Dopamin Dopamin by Dopamin -β- hydroxylase enzyme secretory granules is only converted to norepinephrine. Phenyl ethanol by N-transferase enzyme excess norepinephrine in the central part of the chromaffin cells of the adrenal gland is converted to epinephrine. Also in these cells to Nvrmtanfryn norepinephrine and epinephrine becomes metanephrine well. After relatively minor Nvrmtanfryn and metanephrine products catecholamine metabolism in the central part of the adrenal gland taken into account. les oscars The sympathetic nerves Mnvamyn Aksdaz (MOA) makes norepinephrine on 3 and 4 December hydroxy phenyl glycol (DHPG) is. DHPG by catecholamines Amtyl Trasfraz (COMT) in neural tissue les oscars to 3 methoxy 4-hydroxy-phenyl glycol is metabolized MHPG. MHPG under the influence les oscars of alcohol dehydrogenase in the liver of vanilla Mnvlyk acid (VMA) becomes.
Α-adrenergic receptor norepinephrine and epinephrine through four β acts of their own. Α receptors will respond to both hormone receptor-β but is more influenced by norepinephrine. In the cardiovascular les oscars system, stimulating the β receptors causes increased heart rate, increased cardiac contractility and relaxation of the blood vessels. While not in the heart and stimulates the α receptors in blood vessels with vascular contraction. Β receptors stimulates the release of insulin and decrease blood glucose is associated. les oscars While stimulating the release of insulin les oscars receptor α inhibitors and raises blood glucose. Adrenergic system stimulation with relaxation of the muscles of the respiratory and gastrointestinal systems.
Peptide hormones and catecholamines, which are water soluble plasma membrane les oscars of target cells connected. The hormone binds to the cellular level through intermediate les oscars molecule called messenger of secondary metabolic processes inside the cell communicates. The message inside the cell are: cAMP, a nucleotide derivative of ATP is produced by the Dnylyl cyclase, cGMP made a cyclase Nvklvyvtyd by the Gvanylyl, calcium ions and phosphatidylcholine Aynvzytydha. Second messenger following les oscars Lygant interact with receptors are produced.
Catecholamines, phenyl ethyl amines are in the 3 and 4 positions on the benzene ring and in the side chain methyl ethyl amine and hydroxyl position Darnd.jaygzyny a hydroxyl group in the side chain ethyl amine, separate catecholamines both construction and distinguishes both in terms of performance.
In the central nervous system, norepinephrine, dopamine and serotonin les oscars in the brainstem areas Myshvnd.nvrvn production of norepinephrine in the sympathetic nervous system and the brain stem Fghalyt set the precision les oscars and alertness in the brain on behavior Myknnd.dvpamyn les oscars company reward-seeking influence and to start and keep moving is important. The dopamine neurons in the hypothalamus, the effects of regulation on the release of several les oscars hormones that affect the pituitary gland Darnd.frayndhayy les oscars Srvtvnyk systems (serotonin) that are: memory, learning, behavior, les oscars nutrition, sleep patterns, temperature regulation, pain, cardiovascular function and regulation of pituitary hormones.
In the central part of the chromaffin cells of the adrenal gland epinephrine glands secrete directly into the blood stream to prove that acts on cells away from the release of the hormone epinephrine Mybashnd.apy especially lipolysis, Ktvzhnz, thermogenesis and the Glykvzhnvlyz stimulates gluconeogenesis by stimulating les oscars glucose increases. The powerful effects on lung function and dilate the airways.
_Fyv Krvmvsytvm (adrenal cancer) is associated with increased secretion of norepinephrine and epinephrine, norepinephrine and epinephrine Ast.tshkhys by measuring plasma metanephrine and VMA in the urine test Clonidine suppression that reduces the release of catecholamines Ktvnydyn The natural persons.
HPLC methods for analysis of urinary catecholamines or plasma catecholamines les oscars from plasma and urine using extraction is characterized by several cleanup techniques, such as extraction of aluminum oxide, boric acid gel, organic solvents, de-acid protein, ultrafiltration and there are many ways ...... .qbl analysis of HPLC, extracts using reverse phase chromatography and ion-pairing reagents of HPLC analysis, but in some other method of ion-exchange columns for HPLC the separation les oscars of amines extracted using electrochemical detection measurements Myknnd.bray Mprvmtryk les oscars or Kvlvmtryk use with HPLC separation Myshvd.hmchnyn can be associated with fluorescence detection, but in this case, to increase chemical characteristics and detection limits of the analytical techniques to least before and after the column used. Mass spectrometry les oscars to measure the urinary les oscars tract in a way there is a high capacity and features.
Carl resources A.bvrtys and others, "Clinical Biochemistry Tytz", translation Houshang Amir messenger,